The market for growth hormone is saturated with goods that make the claim that they are just as effective as the therapy with human growth hormone that is approved.
Ibutamoren is one of these products, and it is referred to as a growth hormone secretagogue (GHS) (code names MK-677 and L-163,191). Those who sell it portray it as an alternative treatment for low HGH that is more recent, safer, more convenient, and significantly more cost-effective.
The fact that it does not require daily injections, unlike other growth hormone supplements or human growth hormone, is largely responsible for its widespread acceptance. It’s an HGH stimulant that’s taken orally and isn’t peptide-based.
However, MK-677 is not licenced by the FDA, and there is very little study done on its efficacy and safety. You may only purchase the item illegally, and there is no warranty on the product’s contents or the potential dangers it may pose.
In this post, we will examine the information that has been gathered thus far and give our opinion regarding the benefits and drawbacks of MK-677.
The pituitary gland is stimulated by the pharmacological class that MK-677 belongs to, which causes it to produce more human growth hormone (HGH).
It is a GHS that acts in a manner analogous to the hunger hormone (ghrelin). The hunger response causes an increase in ghrelin, which in turn activates certain receptors that are known as growth hormone estrogenic receptors (GHS-R).
According to the findings of study, stimulating these sensors will cause an increase in your hunger. However, it will also trigger the pituitary gland to create HGH, which helps fight low blood sugar when fasting.
Because it acts similarly to ghrelin, MK-677 is able to activate the GHS-R and boost the body’s natural synthesis of HGH. According to the results of tests conducted on animals, an increase in GH levels occurs between 30 and 40 minutes after oral administration of ibutamoren, and this effect lasts for several hours.
MK-677 has a half-life that is somewhere between four and six hours, which is much longer than that of most GHS. Because it is not composed of peptides, it may be taken by mouth and exert its effect.
Ibutamoren causes an increase in the normal level of insulin-like growth factor-1 as well as an increase in the frequency of growth hormone pulses (IGF-1). The anabolic effects of HGH are mediated by the growth factor IGF-1.
For instance, a study conducted with 65 older participants (aged 60-81) shown that oral administration of 25 milligrammes of MK-677 was sufficient to raise mean levels of HGH and IGF-1 to levels comparable to those of healthy young individuals. The research also showed that using Ipamorelin for an extended period of time (up to two years) was able to successfully sustain high levels of HGH and IGF-1.
On the other hand, there is a dearth of big studies that investigate the effects of MK-677 in a wider variety of demographic groups. It is still a medicine that is being investigated and has not been given approval for sale in the United States.
Therefore, any version of Ibutamoren that is currently for sale on the market is breaking the law and is uncontrolled.
Research with MK-677 is primarily focused on its potential use as a therapy for growth hormone deficiency (GHD) as well as muscular atrophy. Ibutamoren caused a rise in IGF-1 levels of 55 percent after two weeks of treatment, and 88 percent after four weeks of treatment, according to a study that involved 32 healthy senior persons.
However, there has only been one investigation into the usefulness of this treatment in GHD patients. Young adults who have GHD from infancy were given 50 mg of MK-677 daily over a period of four days. IGF-1 levels in the subjects reached a level that was equivalent to the reference values for healthy older people.
At the moment, there are no research available on the effects of Ibutamoren on children. According to the findings of one study, taking MK-677 for one week results in a rise in both HGH and IGF-1 levels; however, the precise effects on long-term growth remain unclear.
According to the findings of a research conducted on younger people who were obese, two months of treatment led to a gain of six pounds of lean mass, largely due to water retention. In either the first study or the subsequent one, the researchers found no evidence of any substantial shifts in the participants’ fat mass.
The previously stated trial that lasted for two years and included sixty-five older participants reported a weight increase of five to seven pounds during the course of the research. Despite the rise in HGH secretion, there was no change in either the amount of fat mass or the strength of the muscles.
There are no research being conducted on the effect of MK-677 on muscle wasting and cachexia at this time.
In addition, the administration of MK-677 resulted in a moderate drop in LDL levels and an increase in bone mineral density. On the other hand, there have not been any reports of significant functional improvements in individuals who suffer bone fractures.
In addition, some healthy individuals who took MK-677 reported an improvement in the amount of time spent in deep sleep as well as a reduction in the amount of time it took to fall asleep.
An increase in hunger is the MK-677 adverse effect that has been reported the most frequently. This is because the ghrelin receptors are triggered when the drug is taken. On the other hand, it seems that the impact is only temporary and that it fades away with continued use.
Ibutamoren causes a temporary rise in cortisol, prolactin, and leptin levels, while patients who take the medication for more than one to two months have an increase in their thyroid hormone levels. In addition to this, it has the potential to lower total testosterone (T) levels while having no effect on free T levels.
Musculoskeletal discomfort, water retention, elevated blood sugar, and insulin resistance were reported in a long-term experiment that lasted for two years and included 65 older participants. At this time, the medicine has not been tried out on cancer patients, and the hazards associated with doing so are yet unclear.
Due to an early safety signal of congestive heart failure in a select group of patients, one of the studies with MK-677 was stopped before it was completed.
As a result of the fact that it is illegal, there is a significant possibility that items may be faked, watered down, or tainted. In point of fact, the majority of illicit vendors incorrectly identify it as a selective androgen receptor modulator (SARM), which is a category of medications having anabolic qualities comparable to those of anabolic steroids.
Users of MK-677 report having experienced benefits such as increased recuperation after exercise, enhanced muscular pump, and improved sleep quality as a result of using the supplement.
A good number of them also took it in the hope that it would repair sports-related injuries. It has been reported by several users that it assisted them in recovering from training-related injuries to their joints and tendons.
The majority of people who have used MK-677 have reported erratic outcomes with regard to their levels of muscle building, fat increase, and water retention. It’s possible that this is because the drug is illegal, and hence there are no regulations in place to ensure its purity.
Because the manufacturers can dilute it or add any number of other ingredients, you can never be sure what effects to anticipate.
Headaches, feelings of hunger and a desire for sugary foods, drowsiness, and increased water retention were the most common adverse effects observed. The majority of users suggest that Ibutamoren be taken in the evening owing to the benefits that it has on encouraging sleep. This is also done in an effort to avoid experiencing excessive appetite and weight gain.
On the other hand, when you begin therapy with legal HGH, you will be under the supervision of a medical practitioner at all times. At each and every appointment, an experienced endocrinologist will evaluate both your findings and the potential for adverse effects.
If there are any issues, your doctor will be able to make the appropriate adjustments to make sure that you continue to receive therapy that is both safe and effective.
At this point in time, the only impacts of MK-677 that have been explored by experts are its short-term effects on the HGH levels of GHD patients. It is entirely uncertain at this time whether or not the medication has the capacity to alleviate the symptoms of a growth hormone deficit.
Patients whose pituitary glands have been badly damaged to the point where they are unable to make HGH may find that MK-677, like the majority of GHS, is utterly useless.
In addition, it is highly unlikely that it would assist people with GHD in managing symptoms such as abdominal obesity. Regrettably, this is one of the most prominent symptoms of the illness, and it frequently results in difficulties over the longer term.
On the other hand, human growth hormone (HGH) replacement therapy includes injecting an exogenous form of recombinant growth hormone, and the success of this treatment does not depend on the pituitary gland’s degree of activity. Numerous research point to its efficiency in treating all of the symptoms associated with GHD, which is supported by these investigations.
At the moment, this medicine is the only one that has been given approval by the FDA to treat the illness.
Both MK-677 and HGH, in terms of their potential adverse effects, may cause a rise in blood sugar as well as insulin resistance and water retention. Ibutamoren, on the other hand, can cause extra adverse effects such as drowsiness, an increase in appetite, a need for sweets, and transient alterations in hormone levels.
Ipamorelin, like MK-677, is a GHS that activates the ghrelin receptor, but it does so in a different way. On the other hand, it possesses a peptide structure and a half-life that is quite a little shorter (about 2 hours). Because of this, it must be injected subcutaneously between two and three times on a daily basis.
Ipamorelin does not have an influence on other hormones like cortisol, prolactin, or leptin; hence, its effects and outcomes appear to be more selective.
Ipamorelin, in contrast to MK-677, produces not just an increase in fat mass but also an increase in both lean mass and food desires, leading to an overall increase in a person’s caloric intake. Consequently, when taking Ipamorelin, the likelihood of you gaining fat rather than reducing it is significantly higher.
GHRP-2 and GHRP-6 are two of the most noteworthy examples of the class of peptides known as growth hormone-releasing peptides (GHRP). In addition, they are GHS, which are responsible for the activation of the ghrelin receptor.
The half-life of GHRP-2 is around 30 minutes, but the half-life of GHRP-6 is between two and three hours. Because of the peptide nature of these substances, they must be injected many times per day.
MK-677 is produced from the growth hormone-releasing peptide GHRP-6, which was the first growth hormone-releasing peptide ever synthesised.
In comparison to ibutamoren, GHRP-6 and GHRP-2 have both been the subject of a significant amount of research.
It has been demonstrated that GHRP-2 is useful in enhancing the growth rate of children with GHD. In addition to this, it is regarded to be more powerful than GHRP-6 in terms of boosting mean levels of HGH and IGF-1.
Ibutamoren’s side effects, which include a rise in water retention, appetite, and weight gain, are also caused by GHRP-6 and GHRP-2. These hormones have the same effect. They are less selective than MK-677, and their levels of production of cortisol rise.