This Is Everything You Needed to Know About SARMs Takeaways from this Article

SARM is an abbreviation for selective androgen receptor modulator, and it refers to a type of medication that is chemically related to anabolic steroids.
SARMs, like steroids, have the ability to enhance muscle building and weight loss, but to a lesser extent.
Additionally, SARMs have many of the same risks, downsides, and bad effects as steroids, including decreased natural testosterone levels, increased hair loss, and, in certain cases, a higher chance of contracting cancer.
You can check how many calories and macronutrients you have consumed.
Give your workouts all of your abilities and dedication.
You’re spending a small fortune on vitamins for your workouts.
In the end, it is all insufficient. It’s simply that the needle isn’t moving as rapidly as you’d want.
Perhaps you’ve entertained the notion of turning to steroids. Though you comprehend their effectiveness, you are also aware of the negative consequences and health concerns associated with them, and you are not prepared to take the chance (har har har).
And then you come across SARMs, and you can’t help but wonder: what exactly are they?

Supposedly, these pills are the “holy grail” of bodybuilding supplements.

Can they really help you gain muscle and reduce fat in a manner that is nearly as effective as steroids, but without any of the negative side effects?
And they’re completely legal and inexpensive!?
It beyond comprehension.
Many people believe that SARMs are the best supplements for health-conscious bodybuilders, and many athletes are praising them for their ability to boost performance while also promoting muscle growth in their bodies.
It surely appears to be too good to be true, but is it? What does the scientific community have to say?
The good news is that this article will get to the bottom of the whole situation.
Specifically, we will look at what SARMs are, how they operate, and what the research has found regarding how effective and safe they are in practise.

What Are SARMs and How Do They Work? How Do SARMs Work?

SARM is an abbreviation for selective androgen receptor modulator, and it refers to a type of medication that is chemically similar to anabolic steroids.
There are numerous different SARMs available on the market, and some are more effective than others and have a larger risk of negative effects.

The most well-liked of them are…

MK-2866 or GTx-024 are two options (Ostarine).
LGD-4033 is a number that represents a digitised version of the LGD-4033 (Ligandrol).

  • LGD-3303.
  • GSX-007 or S-4 are two options (Andarine).
  • GW-501516 is a government identification number (Cardarine).
  • You might wonder why we chose such strange alphanumeric names.

Because SARMs have not been approved for medical use, pharmaceutical marketers have not bothered to refer to them by their proper names. For the time being, they are only available as “research compounds” intended for clinical application; however, more on that in a moment.

Now, in order to understand how these medications function, we must first examine the physiology of hormones.

Hormonal agents are chemical messengers that your body uses to communicate with the cells in your body.

You might think of them as outbound mail that conveys crucial instructions, and when they reach the “mail boxes” of the cells, which are hormone receptors, the instructions are carried out as instructed.

Androgens are hormones that are responsible for the development of masculinity (much deeper voice, facial hair, more muscle and lower body fat levels, etc). The androgen testosterone is the most often used, although there are others as well.

Androgens exert their effects on the body through three basic mechanisms:

It binds to the androgen receptors on the surface of your cells.
DHT is converted into the hormone dihydrotestosterone (DHT), which subsequently attaches to androgen receptors in the male reproductive system.
Transformation into the hormone estradiol (oestrogen), which interacts to a different kind of receptor on cells than the precursor hormone oestrogen (estrogen receptor).
Under normal circumstances, your body meticulously regulates androgen production, relying on sensitive feedback systems to keep hormone levels in check and prevent abnormalities.

When anabolic steroids are introduced into the body, however, your cells get inundated with androgens, which are so abundant that all accessible receptors are completely saturated.

This sends a very powerful message to any cells that are paying attention, including muscle cells, which grow as a result of the message.

That appears to be a nice moment for us weightlifters; yet, there are certain risks associated with it.

Several studies have found that some of the negative effects of steroid use are reversible, while others are not. It is possible to suffer long-term consequences.

Testicular atrophy (shrinking), acne, cysts, greasy hair and skin, higher blood pressure and “bad” cholesterol levels, increased aggression, and lower sperm count are all examples of reversible alterations.

Among the irreversible effects are male-pattern baldness, heart disease, liver disease, and gynecomastia (male breast growth) (breast development).

Another important drawback of steroid use is the possibility of developing biological and mental dependence.

In one research study conducted by doctors at Harvard Medical School, it was shown that 30% of steroid users had an opioid dependent syndrome, and if you chat with enough honest drug users, you’ll learn all about their addictive residential or commercial properties.

Science has been working for years to discover non-addictive steroids or steroid-like medications that are not harmful to people’s health and well-being, and supplement internet marketers claim that SARMs are exactly what they claim.

In this case, non-steroidal anti-androgen medicines were created to activate the androgen receptors in just muscle and bone cells, with no effect on any of the other cells in the body and thus the body’s whole endocrine system as a whole.

A common misconception is that just taking anabolic steroids is the same as carpet-bombing your system with androgens. However, it is negligent and causes a large number of innocent deaths in the process of doing its duty.

Drone strikes against whistleblower reporters… well… I mean, bad guys terrorists… are analogous to drone strikes against bad guys whistleblower reporters.

Instead of the noise and commotion associated with anabolic steroids, SARMs can instruct your muscle cells to develop without the negative side effects.

SARMs do this in two ways, according on their technical specifications:

While they have a strong attraction for certain tissues, such as muscle and bone, they have no such affinity for others, such as the liver, brain, and prostate.
They do not degrade into undesired particles that might produce adverse effects, such as DHT and oestrogen, as readily as other substances.

The second point is particularly important.

One important characteristic of SARMs is that they are not rapidly turned into DHT by an enzyme known as 5-a reductase, which is responsible for a wide range of negative side effects associated with steroid usage.
SARMs are also resistant to the enzyme aromatase, which is responsible for the conversion of testosterone into oestrogen in the body.
Finally, because SARMs are less effective than traditional anabolic steroids, they do not restrict natural testosterone production to the same extent, making them simpler to recover from than traditional steroids.

Anabolic-androgenic steroid hormones (SARMs) are synthetic drugs that mimic many of the actions of testosterone in muscle and bone tissue while having (hopefully) little effect on the rest of the body. As a result, the hypothesis holds that you may have all of the benefits of steroids without any of the negative effects.

Why do people take SARMs as a dietary supplement?
Individuals suffering from illnesses such as muscular wasting, osteoporosis, anaemia, and chronic weariness were among the first to benefit from SARMs.

They were intended to be a far more healthy alternative to testosterone replacement treatment than the latter. It has still to be determined whether or not they will be able to achieve their goals.

SARMs are often used by bodybuilders for one of two reasons: 

(1) to increase muscle mass and

 (2) to increase strength.

For the purpose of “getting their feet wet” with anabolic drug misuse before embarking on typical steroid cycles.

To improve the efficacy of steroid cycles without increasing the risk of adverse effects or health complications.
Numerous bodybuilders also feel that SARMs are particularly useful for cutting since they assist to maintain lean muscle while without increasing water retention, which is a common misconception.

What is the effectiveness of these medications?

According to the findings of the study, SARMs aren’t as effective for muscle gain as conventional steroids, but they are far more effective than anything natural you may consume (like creatine).

Additionally, because they are harder to detect in drug testing, they are popular among athletes as well.

Now, if everything I’ve said thus far has made you want to dash to Google with your money in hand, hold on a sec… we’re not finished yet.

Are synthetic anabolic steroid hormones (SARMs) safe?

Nonsteroidal anti-inflammatory drugs (NSAIDs) have only been available for a few years, and there has been little human research into their effects.

We just do not understand enough about how they function and the possible long-term negative consequences of using them, which is a very real source of anxiety for many people.

Furthermore, because all SARMs sold on the internet are essentially black-market commodities, they are not subject to any kind of regulatory scrutiny, and quality assurance is usually a concern. Mislabeling, contamination, and other antics are commonplace in these situations.

Here’s what we do know about the situation…

SARMs work by inhibiting your body’s natural testosterone production.

One of the most important selling aspects for many of these medicines is the assertion that they do not interfere with your body’s ability to produce testosterone.

This is a fabrication. They most certainly do.

In one study carried out by researchers at the request of GTx, Inc., a pharmaceutical company that specialises in the production of SARMs, male subjects who took 3 mg of the SARM ostarine per day for 86 days experienced a 23 percent drop in totally free testosterone and a 43 percent drop in overall testosterone levels (throughout the trial).

Due to the fact that GTx, Inc. manufactures and distributes SARMs, they had no incentive to make the outcomes appear worse than they were. Rather of reporting bad side effects, they were incentivised to conceal them (there is no evidence that this was done, but I’m just making a point) by the government.

Another trial conducted by researchers at Boston University with the SARM ligandrol yielded findings that were similar to the first. A total of 76 males between the ages of 21 and 50 had a massive 55 percent decline in total testosterone levels after taking 1 mg of ligandrol daily for just three weeks, according to one study. It was also discovered that it took 5 weeks for their natural testosterone production to return to normal.

Because SARMs reduce your levels of luteinizing hormone and follicle-stimulating hormone, which in turn lowers your sperm count and testosterone levels, they are being researched as a male contraceptive.

When you examine the underlying physiology at work, none of this should come as a surprise:

When androgens are introduced into the body, the body recognises the increase and responds by lowering its own production of hormones that are comparable to androgens.

It doesn’t matter what SARM hucksters tell you; SARMs are certain to suppress your natural testosterone production, and the more SARMs you take, the more your natural testosterone levels will decline.

It is likely that the more SARMs you take, the greater the likelihood of experiencing undesirable side effects.
SARMs aren’t totally free of adverse effects; they merely have less of them when used in tiny dosages.

Bodybuilders, on the other hand, do not often utilise tiny doses of steroids, which is why they frequently experience many of the negative effects associated with steroid usage, such as acne and hair loss.

This also pertains to the inhibition of testosterone that you have just learnt about in the previous section. The greater the amount of exogenous (originating outside of an organism) anabolic hormones you introduce into your body, whether through SARMs or plain ol’ testosterone, the greater the decrease in your natural testosterone production.

A study conducted by experts at Copenhagen University found that a drop in natural testosterone production may last for several years after a person stops taking steroids (or SARMs).

On paper, SARMs appear to be less harmful to the body than traditional steroids, which are composed mostly of testosterone. If you take enough to observe major advantages, on the other hand, the chances are strong that you will also suffer significant unfavourable consequences are high.

SARMs are most likely less difficult to recover from than traditional anabolic steroids.

We must remember that they do not convert into DHT or oestrogen in the same manner as steroids do, which means that they do not have the same bad influence on your system as steroids.

Aside from being less anabolic than pure testosterone, SARMs are less likely to reduce natural testosterone levels, which implies that they are less likely to suppress natural testosterone levels (although there isn’t enough evidence available to know for certain).

That being said, if you’re taking enough to reap large advantages, you’re very certainly also taking enough to reap major negative consequences as well. That’s just the nature of drugs: they cut both techniques equally, and you constantly have to consider the advantages and disadvantages of using them.

Some of the more severe negative effects, like as hair loss, gynecomastia, and so on, may be irreversible if you take enough SARMs to cause them, much as it is with anabolic steroid use.

Anecdotally, several people have reported that they recover from SARM usage more quickly than they do from normal steroid cycles. You should, however, take such accounts with a grain of salt because many of these individuals have really also employed far lesser amounts of SARMs than they ever before did of steroids, making it impossible to make an accurate apples-to-apples comparison.

Furthermore, as you’ll see in a minute, it’s very plausible that the substances these folks were ingesting weren’t even SARMs at all.

The negative effects of SARMs may be easier to recover from once you stop using them than the negative effects of regular steroids, however this theory is based primarily on bodybuilder stories rather than rigorous studies.
SARMs may increase your risk of developing cancer.

The SARM cardarine was the subject of a number of large clinical trials that had to be halted because it was generating malignant growths in the digestive tracts of mice.

Some of you may have heard that the doses used were far greater than what we in the fitness industry would ever ingest, but this is not the case.

Because rats excrete some medications from their bodies considerably more quickly than humans do, they require bigger dosages to get the same outcomes as humans.

It was discovered that mice were given 10 mg per kilogramme of cardarine per day in the above-mentioned event; this translates to around 75 mg daily for a 200-pound guy when converted to human metabolic units (see below).

If you look around on bodybuilding discussion sites, you’ll quickly realise that many bodybuilders consume far more than that.

After all, you can’t extrapolate results from rodent study to humans (despite the fact that we share 98 percent of their DNA, we are not giant mice), thus it isn’t obvious whether that medicine or other SARMs truly do raise our risk of developing cancer in the first place.

There is also evidence that SARMs may actually suppress certain types of cancer, so we simply do not know what the outcome will be at this point.

If you ask me, this is just another reason why I feel that SARMs are a high-risk, low-reward concept that should be implemented last and foremost.

Despite the fact that they’re marketed as a less harmful alternative to traditional steroids such as testosterone, they’ve also been studied and understood considerably less thoroughly, which is why many doctors believe SARMs are a riskier option. It is far better to know the devil than it is to know the devil you do not know.

There is evidence that SARMs may raise your risk of developing cancer, and little is known about the overall safety of these medications in general. You’re acting as a test subject, and only time will tell what the outcomes will be when you submit your samples.

A large number of SARM products are not what they claim to be.
We should remind ourselves that SARMs may only be sold legally as “research study substances.”

Put another way, the only individuals who are allowed to purchase SARMs are researchers who are interested in discovering how they operate and whether or not they may be used in therapeutic applications in the pharmaceutical industry.

Naturally, the vast majority of SARMs available for purchase on the internet never make it into a research facility. Instead, they find their way into the bodies of bodybuilders, athletes, and physical fitness enthusiasts who want to get even more ripped.
This opens the door to all kind of skulduggery, including the following:

As a result of inadequate quality control or cost-cutting throughout the manufacturing process, hazardous substances are introduced into the medications.
Using them in combination with weaker and occasionally hazardous drugs in order to boost profitability.
Making them appear to be something they are not in order to increase revenue.
The results of a research conducted by the United States Anti-Doping Agency (USADA) that entailed the purchase of 44 SARM goods from 21 different internet vendors revealed damning proof of this.
The researchers also went a step further by requesting that all of the vendors provide what is known as a “chain-of-custody” of the objects, which identifies which hands the items passed through after they were manufactured (and thus who had the opportunity to damage them).
Following an examination of the items, the experts discovered that…

Only 52 percent of the goods had any evidence of SARMs at all, according to the study.
Approximately one-quarter of the goods included doses that were much lower than those listed on the label.
25 percent of the goods tested contained no or just trace levels of the SARM listed on the label, and instead included unlabeled chemicals such as additional SARMs, as well as the oestrogen blockers androstenetrione and tamoxifen, among other drugs.
Conclusion: SARMs are sold in an unregulated environment that is unlikely to alter in the near future.

There is presently no government agency that forces SARMs producers to follow the rules, and as the report from USADA demonstrates, many manufacturers are well aware of this and are more concerned with making a profit than anything else.

There are a lot of things now being marketed as SARMs that either do not contain any SARMs at all or include other clandestine chemicals and potentially harmful substances.
Basically, SARMs are a bad idea.
SARMs are medications that mimic some of the benefits of anabolic steroids while causing fewer of the negative side effects in the short term.

Despite the fact that they aren’t as effective as steroids, they do much more to stimulate muscle growth than any other natural product on the market. They appear to be more secure as well, but do not assume that this means they are risk-free to use.

The findings of research studies clearly demonstrate that they lower natural testosterone production and have a bad influence on the endocrine system, and there is evidence that they can raise the risk of cancer as well.

Because of the nature of SARMs, we do not know whether or whether there are any long-term health consequences of using them.

There is also strong evidence that many of the products now on the market that are marketed as SARMs may not truly contain SARMs and may instead contain other medications, fillers, and potentially hazardous contaminants.
So, if you’re looking for a straightforward recommendation from me, here it is: Stay away from SARMs.
In my opinion, the hazards exceed the benefits, and they’re just not necessary if you want to build a muscular, powerful, and lean physique that you’ll be proud of.

If you like this post, please consider sharing it on Facebook, Twitter, or any other social media platform that you frequent.

Scientific References
  1. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Identifying of Compounds Marketed as Selective Androgen Receptor Modulators and Sold by means of the Internet. JAMA.
  2. Girroir EE, Hollingshead HE, Billin AN, et al. Peroxisome proliferator-activated receptor-β/ δ (PPARβ/ δ) ligands hinder growth of UACC903 and MCF7 human cancer cell lines. Toxicology. 2008; 243( 1-2):236 -243. doi:10.1016/ j.tox.2007.10.023.
  3. Tachibana K, Yamasaki D, Ishimoto K, Doi T. 2008.
  4. Activation of nuclear hormonal agent receptor peroxisome proliferator-activated receptor-delta accelerates digestive tract adenoma growth. 2004; 10( 3 ):245 -247.
  5. Rasmussen JJ, Selmer C, østergren PB, et al. Former abusers of anabolic androgenic steroids exhibit decreased testosterone levels and hypogonadal symptoms years after cessation: A case-control research study. PLoS One. 2016; 11( 8 ). doi:10.1371/ journal.pone.0161208.
  6. Rahnema CD, Lipshultz LI, Crosnoe LE, Kovac JR, Kim ED. Anabolic steroid-induced hypogonadism: diagnosis and treatment.
  7. Chen J, Hwang DJ, Bohl CE, Miller DD, Dalton JT. A selective androgen receptor modulator for hormone male birth control.
  8. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, an unique nonsteroidal oral, selective androgen receptor modulator, in healthy boys. J Gerontol A Biol Sci Medication Sci. 2013; 68( 1 ):87 -95. doi:10.1093/ gerona/gls078.
  9. Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal ladies: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011; 2( 3 ):153 -161. doi:10.1007/ s13539-011-0034-6.
  10. Androgenic-anabolic steroids and the Olympic Games. 2008; 10( 3 ):384 -390. 2009; 12( 3 ):232 -240.
  11. Gao W, Dalton JT. Expanding the restorative use of androgens through selective androgen receptor modulators (SARMs). Drug Discov Today. 2007; 12( 5-6):241 -248. doi:10.1016/ j.drudis.2007.01.003.
  12. Pharmacodynamics of selective androgen receptor modulators. Ockham’s Razor and Selective Androgen Receptor Modulators( SARMs): Are we ignoring the function of 5α-reductase? Expanding the therapeutic usage of androgens via selective androgen receptor modulators( SARMs ).
  13. Hartgens F, Kuipers H. Results of androgenic-anabolic steroids in professional athletes. 2004; 34( 8 ):513 -554.
  14. Br J Pharmacol. 2008; 154( 3 ):502 -521.
  15. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Structure and Labeling of Compounds Marketed as Selective Androgen Receptor Modulators and Offered via the Internet. Tachibana K, Yamasaki D, Ishimoto K, Doi T. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy postmenopausal women and elderly males: outcomes of a double-blind, placebo-controlled phase II trial. Expanding the restorative use of androgens through selective androgen receptor modulators (SARMs). Broadening the restorative usage of androgens through selective androgen receptor modulators( SARMs ).
Related Articles: Learn More (Proven SARMs): Sarms Capsules for sale Sarms droppers for sale Sarms stack for sale Shop Read More: HealthLine (What Is SARMs) WikiPedia
Select your currency
GBP Pound sterling
EUR Euro