Benefits of S-4?

Andarine (S4) Uses, Dangers & Side Effects

Andarine is a SARM that was created as a treatment for the loss of muscle as well as osteoporosis. In animal trials, it enhanced bone density and muscle mass, thus there is reason to be optimistic about its potential. However, in the early stages of human clinical testing, it was discontinued due to significant safety concerns. Bodybuilding blogs frequently play down the risks, which leads many people who continue to engage in illicit usage of the substance to remain oblivious to them. Continue reading to find out more information on this medication and its potential adverse effects.

Disclaimer: Because of the lack of information on its effects and safety, we strongly advise against the use of this substance. Because of this, we have decided to share the information that is readily available from the clinical and scientific literature in the hopes that it would assist readers in better comprehending the risks that are involved.

Andarine: What Is it?

Andarine is a selective androgen receptor modulator (SARM) that was created with the intention of treating osteoporosis and muscle wasting. It is also known as S-4, S-40503, or 8.

SARMs, which stands for selective androgen receptor modulators, are pharmaceuticals that have been designed to bind to the androgen receptor (AR). The AR is the primary site of action for the hormone testosterone.

In the early days of the study of SARMs, andarine was considered to be the perfect SARM due to its high oral bioavailability as well as its outstanding benefits on developing muscle and bone (tested in animals) [1].

It has been stated that the Phase I human trials using this medicine have been effective, however there have been no papers published. However, further research of the medication was halted in favour of ostarine, which is also referred to as S-22 and is another SARM with a structure very similar to that of S-22 [2].

This was most likely due to the unsatisfactory safety profile of andarine. It produced negative effects relating to eyesight, which is another reason to add to the already extensive list of arguments against ever using this medicine.

The Workings of the Mechanism

Because of its strong affinity for the androgen receptor (AR), andarine can have effects that are similar to those of testosterone. On the other hand, its effects are far more pronounced in the body’s skeletal muscles and bones than in the reproductive organs. It is for this reason that it is predicted that andarine and other SARMs would result in less adverse effects than anabolic steroids [3].

Bodybuilders have a tendency to use this unapproved notion as “proof” that they won’t have to cope with significant testosterone suppression and elevated estrogens if they take SARMs. However, this hypothesis is not supported by scientific evidence. However, this is not even close to being accurate.

In point of fact, it’s possible that the “SARMs selectivity idea” is totally made up. It has never been demonstrated, and selective androgen receptor modulators (SARMs) like andarine and ostarine have never been successful in clinical studies. It’s possible that SARMs will turn out to be far more harmful than originally believed.

Andarine may have a variety of applications.

The clinical studies and scientific investigations on Andarine that have been conducted up to this point are the primary topics of discussion in this section.

Anadarine has never been subjected to adequate research in human subjects.

According to the evidence that is now available, its effects are unclear, and the likelihood that it may cause harm is high.

1) May Lead to an Increase in Total Muscle Mass

This medication was originally intended to stop the breakdown of muscle tissue, and research conducted on animals demonstrates that andarine promotes both increased muscle development and strength in those subjects.

Andarine caused a significant increase in muscle weight in castrated rats after being administered to the animals for a period of four weeks (dihydrotestosterone). In addition, in contrast to DHT, andarine did not result in an enlarged prostate, which is a potential side effect of steroid usage [4].

Andarine was able to successfully recover the amount of lean body mass (muscle) in rats twelve weeks following castration [5].

2) Could Improve Bone Strength While Also Helping to Fight Osteoporosis

Both castrated male rats and female rats whose ovaries had been removed (this is a regularly used animal model of osteoporosis) showed an improvement in bone mineral density and strength when treated with andarine [4, 5, 6, 7].

Andarine may be particularly useful in the treatment of osteoporosis because, in addition to increasing bone density, it also increases muscular strength, which, in turn, may help lower the risk of fractures and falls [7].

3) Fat Loss

Andarine was shown to reduce body fat in female rats who had their ovaries surgically removed [7], in addition to enhancing bone strength in these rats.

Andarine’s adverse effects, on the other hand, may help you avoid becoming sick and stave off infections by improving your overall health.
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Serious Concerns Regarding Public Safety

Andarine is a medicine that has not been approved for use, and its effects on the body are entirely unknown.

It is speculated that the use of SARMs will result in fewer adverse effects than the use of anabolic steroids. This has not been demonstrated.

A fundamental misunderstanding of the existing scientific evidence, which is emphasised in a variety of bodybuilding blogs, leads people to mistakenly believe that SARMs like andarine are safer than they actually are.

On the other hand, the “SARMS selectivity theory,” which is the foundation for the argument that there are fewer adverse effects, has never been verified. SARMs like andarine have never been put through the required clinical testing. It’s possible that SARMs will turn out to be significantly riskier than a lot of other drugs (steroids and testosterone included).

The hormones luteinizing hormone (LH) and follicle stimulating hormone (FSH) are responsible for increasing the synthesis of reproductive hormones in both men and women. If LH and FSH levels are reduced, normal oestrogen and testosterone levels may also be reduced. Andarine was able to reduce the levels of LH and FSH in castrated rats, which had increased levels of both hormones as a result of the castration procedure. Normal male rats, on the other hand, showed no signs of any impact [8, 3].

It is uncertain whether or not andarine might inhibit testosterone or oestrogen production in people or to what degree such inhibition would occur.

Visual difficulties, such as a yellow tint and trouble adapting to night vision, are the ones that cause users to report experiencing adverse effects the most frequently. After stopping taking the medication, these symptoms will go away. It appears that higher dosages generate more severe adverse effects. Depression has been reported by a few users as well.

Restrictions and Notes of Caution

Andarine’s risks and benefits to human subjects have either not been investigated, or the relevant research have not been made available to the general public. The primary subjects for this pharmacological study were rats.

Although it may be bought online, it is uncertain whether or not it has any long-term advantages or hazards for people.

Doping, Legality, and Sports Legality, Sports, and Doping

Since 2008, the United States Anti-Doping Agency (USADA) has deemed the use of SARMs to constitute cheating, and these medications are included on the list of those that are forbidden by the World Anti-Doping Agency (WADA) [9].

Because of this, it is against the law for athletes to use andarine in competitive and professional sports.

The Food and Drug Administration has not given its blessing for any use of this medication.


Because it has not been subjected to adequate clinical testing or been granted clearance by any regulatory agency, there is no known safe dosage for this medication.

Andarine is bioavailable in rats and dogs, and its half-life is around 200 minutes on average [10, 11].

In this article, we have included a summary of the dose data that is currently accessible from online forums in an effort to further alert consumers about the risks associated with using an unapproved medicine.

Users report that the typical dosage range is between 50 and 75 milligrammes per day (divided into 3 doses taken with meals). Some people begin treatment with much lower dosages, ranging from 25 to 50 mg per day. Andarine is rotated rather frequently.

Since this medication has not been given official approval, there is a great deal of uncertainty regarding both its quality and its identity. Only 52 percent of the items that were promoted as SARMs (including Andarine) truly included SARMs, and many of the goods had misleading labels [12].

Before taking any medicine, especially an unscheduled substance with poor long-term safety evidence in humans, we here at strongly recommend consulting with a medical professional.

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